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1

Novel N-terminal Cleavage of APP Precludes Aβ Generation in ACAT-Defective AC29 Cells

Henri J. Huttunen, Luigi Puglielli, Blake C. Ellis, Laura A. MacKenzie Ingano, Dora M. Kovacs

Journal:

Journal of Molecular Neuroscience

Year:

2009

Language:

english

File:

PDF, 363 KB

english, 2009

2

Altered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature death

Mariana Pehar, Kenneth J. O’Riordan, Melissa Burns-Cusato, Matthew E. Andrzejewski, Carlos Gil Del Alcazar, Corinna Burger, Heidi Scrable, Luigi Puglielli

Journal:

Year:

2010

Language:

english

File:

PDF, 1.23 MB

english, 2010

3

PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1

Jonas, Mary Cabell, Costantini, Claudio, Puglielli, Luigi

Journal:

Year:

2008

Language:

english

File:

PDF, 360 KB

english, 2008

4

10.1038/ncb1001-905

Puglielli, Luigi, Konopka, Genevieve, Pack-Chung, Eunju, Ingano, Laura A. MacKenzie, Berezovska, Oksana, Hyman, Bradley T., Chang, Ta Yuan, Tanzi, Rudolph E., Kovacs, Dora M.

Journal:

Nature Cell Biology

Year:

2001

Language:

english

File:

PDF, 249 KB

english, 2001

5

Alzheimer's disease: the cholesterol connection

Puglielli, Luigi, Tanzi, Rudolph E., Kovacs, Dora M.

Journal:

Nature Neuroscience

Year:

2003

Language:

english

File:

PDF, 239 KB

english, 2003

6

An aging pathway controls the TrkA to p75NTR receptor switch and amyloid β-peptide generation

Costantini, Claudio, Scrable, Heidi, Puglielli, Luigi

Journal:

The EMBO Journal

Year:

2006

Language:

english

File:

PDF, 447 KB

english, 2006

7

Role of acyl-coenzyme A

Luigi Puglielli, Blake C. Ellis, Laura A. MacKenzie Ingano, Dora M. Kovacs

Journal:

Journal of Molecular Neuroscience

Year:

2004

Language:

english

File:

PDF, 75 KB

english, 2004

8

Cholesterol crystallization-promoting activity of aminopeptidase-N isolated from the vesicular carrier of biliary lipids

Liliana Núñez, Ludwig Amigo, Attilio Rigotti, Luigi Puglielli, Geltrude Mingrone, Aldo Virgilio Greco, Flavio Nervi

Journal:

Year:

1993

Language:

english

File:

PDF, 690 KB

english, 1993

9

Aging of the brain, neurotrophin signaling, and Alzheimer's disease: Is IGF1-R the common culprit?

Luigi Puglielli

Journal:

Neurobiology of Aging

Year:

2008

Language:

english

File:

PDF, 867 KB

english, 2008

10

Egr-1 and Hipk2 are required for the TrkA to p75NTR switch that occurs downstream of IGF1-R

Hui Li, Claudio Costantini, Heidi Scrable, Richard Weindruch, Luigi Puglielli

Journal:

Neurobiology of Aging

Year:

2009

Language:

english

File:

PDF, 1.08 MB

english, 2009

11

The ACAT Inhibitor CP-113,818 Markedly Reduces Amyloid Pathology in a Mouse Model of Alzheimer's Disease

Birgit Hutter-Paier, Henri J. Huttunen, Luigi Puglielli, Christopher B. Eckman, Doo Yeon Kim, Alexander Hofmeister, Robert D. Moir, Sarah B. Domnitz, Matthew P. Frosch, Manfred Windisch, Dora M. Kovac

Journal:

Year:

2004

Language:

english

File:

PDF, 552 KB

english, 2004

12

The ACAT Inhibitor CP-113,818 Markedly Reduces Amyloid Pathology in a Mouse Model of Alzheimer's Disease

Birgit Hutter-Paier, Henri J. Huttunen, Luigi Puglielli, Christopher B. Eckman, Doo Yeon Kim, Alexander Hofmeister, Robert D. Moir, Sarah B. Domnitz, Matthew P. Frosch, Manfred Windisch, Dora M. Kovac

Journal:

Year:

2010

Language:

english

File:

PDF, 187 KB

english, 2010

13

Presenilin 1 processing in cholesterol mutant cells treated with proteasome inhibitors

Laura A. MacKenzie Ingano, Kristen M. Lentini, Luigi Puglielli, Rudolph E. Tanzi, Dora M. Kovacs

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 183 KB

english, 2000

14

Effect of familial Alzheimer's disease mutations on the formation of presenilin aggregates in proteasome inhibitor treated cells

Dora M. Kovacs, Imre Kovacs, Kristen M. Lentini, Laura A. MacKenzie Ingano, Luigi Puglielli, Rudolph E. Tanzi

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 183 KB

english, 2000

15

Presenilin-containing aggresome formation in cholesterol mutant cells

Imre Kovacs, Kristen M. Lentini, Laura A. MacKenzie Ingano, Luigi Puglielli, Rudolph E. Tanzi, Dora M. Kovacs

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 184 KB

english, 2000

16

Role of intracellular cholesterol compartmentation in APP processing and Aβgeneration

Luigi Puglielli, Genevieve Konopka, Laura A. Mackenzie Ingano, Rudolph E. Tanzi, Dora M. Kovacs

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 194 KB

english, 2000

17

Ceramide and Cholesterol: Possible Connections Between Normal Aging of the Brain and Alzheimer’s Disease. Just hypotheses or molecular pathways to be identified?

Claudio Costantini, Rekha M.K. Kolasani, Luigi Puglielli

Journal:

Alzheimer's & Dementia

Year:

2005

Language:

english

File:

PDF, 266 KB

english, 2005

18

O1-04-07: CSF and MRI perfusion biomarkers in middle-aged adults at risk for Alzheimer’s disease: Influence of APOE4 allele

Cynthia M. Carlsson, Zhifei Wen, Guofan Xu, Howard A. Rowley, George C. Newman, Jodi H. Barnet, Carey E. Gleason, Luigi Puglielli, Karl K. Vigen, Alan B. McMillan, Rachel D. McKinsey, John M. Ollinger

Journal:

Alzheimer's & Dementia

Year:

2007

Language:

english

File:

PDF, 151 KB

english, 2007

19

Mid-life dementia risk scores as a predictor of CSF biomarker response to simvastatin therapy in asymptomatic adults at risk for Alzheimer's disease: The ESPRIT study

Alyce J. Marsh, Jodi H. Barnet, Hanna M. Blazel, Carey E. Gleason, Sterling C. Johnson, Henrik Zetterberg, Kaj Blennow, Bruce P. Hermann, N. Maritza Dowling, Luigi Puglielli, Craig S. Atwood, Mark A.

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 114 KB

english, 2010

20

Genetic epidemiology of cholesterol cholelithiasis among Chilean Hispanics, Amerindians, and Maoris

Juan Francisco Miquel, Carmen Covarrubias, Luis Villaroel, Geltrude Mingrone, Aldo V. Greco, Luigi Puglielli, Pilar Carvallo, Guillermo Marshall, Guido Del Pino, Flavio Nervi

Journal:

Gastroenterology

Year:

1998

Language:

english

File:

PDF, 133 KB

english, 1998

21

Notes and News

Puglielli, Luigi, Cattrini, Corrado, Garcés Resa, JoséJulian, Velásques, Maria, Garcia, LuisMiguelLeon

Journal:

Year:

1976

Language:

english

File:

PDF, 294 KB

english, 1976

22

Symptomless carriage of Vibrio cholerae in Peru

Puglielli, Luigi, Cattrini, Corrado, Garcés Resa, JoséJulian, Velásques, Maria, Garcia, LuisMiguelLeon

Journal:

Year:

1992

Language:

english

File:

PDF, 337 KB

english, 1992

23

Baseline cerebrospinal fluid markers in healthy middle-aged adults predict brain health at three-year follow-up

Bendlin, Barbara, Sodhi, Aparna, Willette, Auriel, Johnson, Sterling, Ries, Michele, Hawley, Amy, Alexander, Andrew, Puglielli, Luigi, Asthana, Sanjay, Zetterberg, Henrik, Blennow, Kaj, Sager, Mark

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 157 KB

english, 2011

24

P3-062: Relationship of atherogenic lipid profiles and gender with CSF biomarkers in middle-aged adults at risk for Alzheimer's disease

Carlsson, Cynthia M., Barnet, Jodi, Blazel, Hanna M., Puglielli, Luigi, Atwood, Craig S., Gleason, Carey E., Johnson, Sterling C., Sager, Mark A., Asthana, Sanjay

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 130 KB

english, 2008

25

Relationship between CSF biomarkers and language fluency in asymptomatic middle-aged adults at increased risk for Alzheimer's disease: The ESPRIT study

Blazel, Hanna M., Barnet, Jodi, Gleason, Carey E., Dowling, N. Maritza, Hermann, Bruce P., Johnson, Sterling C., Zetterberg, Henrik, Blennow, Kaj, Marsh, Alyce, Puglielli, Luigi, Atwood, Craig, Sager,

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 106 KB

english, 2010

26

Post-Translational Regulation of CD133 by ATase1/ATase2-Mediated Lysine Acetylation

Mak, Anthony B., Pehar, Mariana, Nixon, Allison M.L., Williams, Rashida A., Uetrecht, Andrea C., Puglielli, Luigi, Moffat, Jason

Journal:

Journal of Molecular Biology

Year:

2014

Language:

english

File:

PDF, 1013 KB

english, 2014

27

Lysine acetylation in the lumen of the ER: A novel and essential function under the control of the UPR

Pehar, Mariana, Puglielli, Luigi

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2013

Language:

english

File:

PDF, 1014 KB

english, 2013

28

The relationship of cerebral perfusion with age and CSF measures in middle-aged adults at risk for Alzheimer's disease

Austin, Benjamin, Bendlin, Barbara, Johnson, Sterling, Zetterberg, Henrik, Blennow, Kaj, Blazel, Hanna, Barnet, Jodi, Dowling, Maritza, Puglielli, Luigi, Gleason, Carey, Sager, Mark, Asthana, Sanjay,

Journal:

Alzheimer's & Dementia

Year:

2013

Language:

english

File:

PDF, 332 KB

english, 2013

29

The relationship of cerebral perfusion with age and CSF measures in middle-aged adults at risk for Alzheimer's disease

Austin, Benjamin, Bendlin, Barbara, Johnson, Sterling, Zetterberg, Henrik, Blennow, Kaj, Blazel, Hanna, Barnet, Jodi, Dowling, Maritza, Puglielli, Luigi, Gleason, Carey, Sager, Mark, Asthana, Sanjay,

Journal:

Alzheimer's & Dementia

Year:

2013

Language:

english

File:

PDF, 658 KB

english, 2013

30

Identification of first and second generation ATase1 and ATase2 inhibitors that reduce BACE1 levels and Aβ generation

Ding, Yun, Puglielli, Luigi, Ko, Mi Hee, Pehar, Mariana

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 51 KB

english, 2011

31

CSF sphingolipid levels correlate with CSF beta-amyloid and tau

Mielke, Michelle, Haughey, Norman, Ratnam Bandaru, Veera Vankata, Zetterberg, Henrik, Johnson, Sterling, Gleason, Carey, Blazel, Hanna, Puglielli, Luigi, Sager, Mark, Asthana, Sanjay, Carlsson, Cynthi

Journal:

Alzheimer's & Dementia

Year:

2013

Language:

english

File:

PDF, 87 KB

english, 2013

32

P44, the ‘longevity-assurance’ isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion

Pehar, Mariana, Ko, Mi Hee, Li, Mi, Scrable, Heidi, Puglielli, Luigi

Journal:

Year:

2014

Language:

english

File:

PDF, 726 KB

english, 2014

33

Proteomic Assessment Shows That Many Endoplasmic Reticulum (ER)-resident Proteins Are Targeted by N ϵ -Lysine Acetylation in the Lumen of the Organelle and Predicts Broad Biological Impact

Pehar, Mariana, Lehnus, Massimiliano, Karst, Anna, Puglielli, Luigi

Journal:

Journal of Biological Chemistry

Year:

2012

Language:

english

File:

PDF, 1.77 MB

english, 2012

34

The amyloid precursor protein (APP) intracellular domain regulates translation of p44, a short isoform of p53, through an IRES-dependent mechanism

Li, Mi, Pehar, Mariana, Liu, Yan, Bhattacharyya, Anita, Zhang, Su-Chun, O'Riordan, Kenneth J., Burger, Corinna, D'Adamio, Luciano, Puglielli, Luigi

Journal:

Neurobiology of Aging

Year:

2015

Language:

english

File:

PDF, 2.07 MB

english, 2015

35

Impairment of the Golgi GDP-l-Fucose Transport and Unresponsiveness to Fucose Replacement Therapy in LAD II Patients

Sturla, Laura, Puglielli, Luigi, Tonetti, Michela, Berninsone, Patricia, Hirschberg, Carlos B, de Flora, Antonio, Etzioni, Amos

Journal:

Pediatric Research

Year:

2001

Language:

english

File:

PDF, 1.24 MB

english, 2001

36

A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1

Costantini, Claudio, Ko, Mi Hee, Jonas, Mary Cabell, Puglielli, Luigi

Journal:

Biochemical Journal

Year:

2007

Language:

english

File:

PDF, 858 KB

english, 2007

37

A TrkA-to-p75 NTR molecular switch activates amyloid β-peptide generation during aging

Costantini, Claudio, Weindruch, Richard, Della Valle, Giuliano, Puglielli, Luigi

Journal:

Biochemical Journal

Year:

2005

Language:

english

File:

PDF, 575 KB

english, 2005

38

Improved proteostasis in the secretory pathway rescues Alzheimer’s disease in the mouse

Peng, Yajing, Kim, Mi Jin, Hullinger, Rikki, O’Riordan, Kenneth J., Burger, Corinna, Pehar, Mariana, Puglielli, Luigi

Journal:

Year:

2016

Language:

english

File:

PDF, 2.10 MB

english, 2016

39

Modulation of intrahepatic cholesterol trafficking: evidence by in vivo antisense treatment for the involvement of sterol carrier protein-2 in newly synthesized cholesterol transport into rat bile

PUGLIELLI, Luigi, RIGOTTI, Attilio, AMIGO, Ludwig, NUÑEZ, Liliana, GRECO, Aldo V., SANTOS, Manuel J., NERVI, Flavio

Journal:

Biochemical Journal

Year:

1996

Language:

english

File:

PDF, 505 KB

english, 1996

40

N ϵ -lysine acetylation in the lumen of the endoplasmic reticulum: A way to regulate autophagy and maintain protein homeostasis in the secretory pathway

Peng, Yajing, Puglielli, Luigi

Journal:

Year:

2016

Language:

english

File:

PDF, 702 KB

english, 2016

41

Molecular and cellular aspects of age-related cognitive decline and Alzheimer’s disease

Hullinger, Rikki, Puglielli, Luigi

Journal:

Behavioural Brain Research

Year:

2016

Language:

english

File:

PDF, 415 KB

english, 2016

42

Increased expression of AT-1/SLC33A1 causes an autistic-like phenotype in mice by affecting dendritic branching and spine formation

Hullinger, Rikki, Li, Mi, Wang, Jingxin, Peng, Yajing, Dowell, James A., Bomba-Warczak, Ewa, Mitchell, Heather A., Burger, Corinna, Chapman, Edwin R., Denu, John M., Li, Lingjun, Puglielli, Luigi

Journal:

Journal of Experimental Medicine

Year:

2016

Language:

english

File:

PDF, 2.71 MB

english, 2016

43

Protective role of biliary cholesterol and phospholipid lamellae against bile acid-induced cell damage

Puglielli, Luigi, Amigo, Ludwig, Arrese, Marco, Núñez, Liliana, Rigotti, Attilio, Garrido, Jorge, González, Sergio, Mingrone, Geltrude, Greco, Aldo V., Accatino, Luigi, Nervi, Flavio

Journal:

Gastroenterology

Year:

1994

Language:

english

File:

PDF, 1.44 MB

english, 1994

44

Effects of Simvastatin on Cerebrospinal Fluid Biomarkers and Cognition in Middle-Aged Adults at Risk for Alzheimer's Disease

Carlsson, Cynthia M., Gleason, Carey E., Hess, Timothy M., Moreland, Kimberly A., Blazel, Hanna M., Koscik, Rebecca L., Schreiber, Nathan T.N., Johnson, Sterling C., Atwood, Craig S., Puglielli, Luigi

Journal:

Journal of Alzheimer's Disease

Year:

2008

Language:

english

File:

PDF, 92 KB

english, 2008

45

Insulin Resistance is Associated with Higher Cerebrospinal Fluid Tau Levels in Asymptomatic APOE ɛ4 Carriers

Starks, Erika J., Patrick O’Grady, J., Hoscheidt, Siobhan M., Racine, Annie M., Carlsson, Cynthia M., Zetterberg, Henrik, Blennow, Kaj, Okonkwo, Ozioma C., Puglielli, Luigi, Asthana, Sanjay, Dowling,

Journal:

Journal of Alzheimer's Disease

Year:

2015

Language:

english

File:

PDF, 163 KB

english, 2015

46

Right Ventricular Aneurysm: A New Prognostic Indicator after a First Acute Myocardial Infarction

Incalzi, Raffaele Antonelli, Capparella, Oliviero, Gemma, Antonella, Puglielli, Luigi, Bonetti, Massimo Giuliano, Carbonin, Pierugo

Journal:

Year:

1991

Language:

english

File:

PDF, 887 KB

english, 1991

47

GSK3β Regulates Brain Energy Metabolism

Martin, Stephen A., Souder, Dylan C., Miller, Karl N., Clark, Josef P., Sagar, Abdul Kader, Eliceiri, Kevin W., Puglielli, Luigi, Beasley, T. Mark, Anderson, Rozalyn M.

Journal:

Year:

2018

Language:

english

File:

PDF, 4.16 MB

english, 2018

48

320 - A Novel Genetic Model of Progressive Chronic Pancreatitis Caused by Impairment of the Endoplasmic Reticulum Acetyl-COA Transporter AT-1

Cooley, Michelle, Thomas, Diana, Deans, Kali, Peng, Yajing, Puglielli, Luigi, Groblewski, Guy E.

Journal:

Gastroenterology

Year:

2018

Language:

english

File:

PDF, 131 KB

english, 2018

49

Developing BACE-1 inhibitors for FXS

Westmark, Cara J., Berry-Kravis, Elizabeth M., Ikonomidou, Chrysanthy, Yin, Jerry C. P., Puglielli, Luigi

Journal:

Frontiers in Cellular Neuroscience

Year:

2013

Language:

english

File:

PDF, 2.29 MB

english, 2013

50

Nε-lysine acetylation in the endoplasmic reticulum – a novel cellular mechanism that regulates proteostasis and autophagy

Farrugia, Mark A., Puglielli, Luigi

Journal:

Journal of Cell Science

Year:

2018

Language:

english

File:

PDF, 517 KB

english, 2018